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Polycystic Kidney Disease& Kidney Cysts

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PKD & Kidney Cysts

Polycystic kidney disease (PKD) is a group of disorders that result from the formation and progressive enlargement of cysts in the kidneys without dysplasia, usually leading to renal failure.

It Is Likely to Develop Kidney Failure Before 60 Years Old for PKD Patients

2018-10-27 07:35

It Is Likely to Develop Kidney Failure Before 60 Years Old for PKD PatientsDue to gene pathogenic mutations, numerous cysts grow in the kidneys. With the growth of renal cysts, they gradually oppress and damage kidney tissues, leading to impaired renal function, and then symptoms such as proteinuria, high blood pressure, elevation of creatinine level, UTIs, urine stones, etc. Eventually uremia occurs, and then you have to start dialysis or kidney transplant.

Today we will talk about ADPKD.

Polycystic kidney disease(PKD) includes autosomal dominant polycystic kidney disease (ADPKD) and autosomal recessive polycystic kidney disease(ARPKD). The incidence of ARPKD is low, and mostly in children. ADPKD is more common in adults. Here PKD refers to ADPKD.

How does PKD progress?

It is a kind of hereditary kidney disease. Its occurrence and development also have certain rules, and the stages of PKD has the following rules.

1. Occurrence period: patients were born to have renal cysts. The cysts are too small to be detected before 20 years old.

2. Growth period: the patients are in 30 ~ 40 years old, and cysts will have a faster growth. If we can find them early, we can make the cysts no longer grow or delay the growth rate of the cysts by using the traditional Chinese medicine with strong promoting blood circulation and removing blood stasis so as to extend the life of the patient.

3. Enlargement period: When patients enter 40 years old, renal cysts will grow further, and symptoms such as back pain, proteinuria, hematuria and high blood pressure will appear. At this time, the combination of Chinese medicine and western medicine can be applied to protect renal function. Chinese medicine can activate blood circulation, discharge toxins and drain renal cysts so as to achieve the goal of protecting renal function.

4. Rupture period: with the progression, renal cysts will enlarge further so that pressure in cyst increases, bilateral kidneys will also enlarge, and intraperitoneal pressure increases. At this time, a slight injury, such as sprain, bruise and fall can increase the internal pressure of abdominal dirty or external trauma directly to the impact of swelling cyst, promoting the rupture of cyst with high internal pressure, bleeding, very easy to induce infection.

5. Uremia period. In general, before 60 years old, it can develop uremia. Male with PKD1 gene mutation have hypertension, urinary protein, and urinary tract infection before the age of 35, which are characteristics of rapid progression to uremia and need to be closely monitored.

Tolvaptan delays the deterioration of PKD.

PKD patients should control diet, prevent infections, prevent trauma and control blood pressure. The drug, which has recently been approved by the FDA as the first treatment for the rapidly progressing, high-risk PKD is the best choice for patients with PKD. Several clinical trials have shown that Tolvaptan can significantly slow down the rate of deterioration of renal function in patients with PKD.

At present, there is no effective drug for the treatment of PKD, so only symptomatic treatment can be adopted. Patients with high blood pressure will be given medicine to reduce pressure, and patients with pain will be given medicine to relieve pain. And there is no way to control the disease itself.

Tolvaptan, a vasopressin receptor 2 antagonist, can reduce the occurrence and growth of multiple renal vesicles and slow the progression of the disease. It is the first therapeutic drug for the pathogenesis of polycystic kidney. It can also significantly reduce the risk of multiple events such as deterioration of renal function, renal pain, hypertension or proteinuria.

This drug has good tolerance, and its main adverse reactions are dry mouth, thirst, frequent urination, and the risk of liver damage in some patients. Therefore, it is recommended that patients should monitor liver function every month in the first 18 months after taking the drug, and then monitor liver function every 3 months. It has to be said that it brings new hope to patients with polycystic kidney disease.

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